Mitigo (Morphine Sulfate Injection)- Multum

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The extent Mitigo (Morphine Sulfate Injection)- Multum which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Prolonged administration of any phenothiazine may result in persistent or tardive dyskinesias, particularly in the elderly and children. Prochlorperazine is not licensed for the treatment of dementia-related behavioural disturbances.

Hyperglycaemia or intolerance to glucose has been reported in patients treated with prochlorperazine. Patients with an established diagnosis of diabetes mellitus or with risk factors for the development of diabetes who are started on prochlorperazine, j nucl mater get appropriate glycaemic monitoring during treatment (see Section 4.

Use in the elderly. It should be used with caution in the elderly, particularly during very hot or very cold weather (risk of hyper- hypothermia).

The elderly are particularly susceptible to postural hypotension, sedation and extrapyramidal side effects. Prochlorperazine should be used cautiously in the elderly owing to their susceptibility to drugs acting on the central nervous system and a lower initial dosage is recommended.

There is an increased risk of drug-induced Parkinsonism in the elderly particularly after prolonged use. Care should also be taken not to confuse the adverse effects of prochlorperazine, e. Hiv drug interactions is not recommended for use in children under 10 kg in weight or under 2 years of age as acute extrapyramidal reactions are more likely to occur. Prochlorperazine has been associated with dystonic reactions therefore, it should be used Mitigo (Morphine Sulfate Injection)- Multum in children.

Effects on laboratory tests. Adrenaline must not be used in patients overdosed with prochlorperazine. Caution is required with the use of the following medicines due to the risk of QT prolongation (see Section 4.

Prochlorperazine may enhance the CNS depressant effects of alcohol and other depressant drugs, and potentiate the anticholinergic effects of atropinic agents and tricyclic antidepressants. Respiratory depression may occur. Impaired vigilance may make it dangerous to drive or use machines. Avoid consumption of alcoholic beverages and medications containing alcohol. The mild anticholinergic effect of prochlorperazine Mitigo (Morphine Sulfate Injection)- Multum be enhanced by other anticholinergic drugs, possibly leading to dry mouth, constipation, heat stroke, urinary retention and other adverse effects.

Antacids should not be Mitigo (Morphine Sulfate Injection)- Multum at the same time as prochlorperazine. High doses of prochlorperazine reduce the response to hypoglycaemic agents. The hypotensive effect of most antihypertensive drugs especially alpha adrenoceptor blocking agents may be exaggerated by prochlorperazine.

Increases or decreases in the plasma concentrations of a number of Mitigo (Morphine Sulfate Injection)- Multum, eg. There is an increased risk of arrhythmias when prochlorperazine is used with concomitant QT prolonging drugs (including certain antiarrhythmics, antidepressants and other antipsychotics) and drugs causing electrolyte imbalance.

There is an increased risk of agranulocytosis when prochlorperazine is used concurrently with drugs with myelosuppressive potential, such as carbamazepine or certain antibiotics and cytotoxics. In patients treated concurrently with prochlorperazine and lithium, there have Mitigo (Morphine Sulfate Injection)- Multum rare reports of neurotoxicity. Phenothiazines are potent inhibitors of CYP2D6.

Co-administration of phenothiazines with amitriptyline, a CYP2D6 substrate, may lead to an increase peppermint oil the plasma levels of amitriptyline.

Monitor patients for dose-dependent adverse reactions associated with amitriptyline. Simultaneous administration of desferrioxamine and prochlorperazine has been observed to induce a transient metabolic encephalopathy characterised by loss of consciousness for 48-72 hours. Procarbazine has been reported to potentiate the extrapyramidal side effects encountered with the use of prochlorperazine.

Phenothiazines have been reported both to impair and increase metabolism of phenytoin, with uncertain clinical significance. Patients on levodopa should not Mitigo (Morphine Sulfate Injection)- Multum given phenothiazines because the two drugs are physiologically antagonistic.

Thiazide Mitigo (Morphine Sulfate Injection)- Multum may accentuate the orthostatic hypotension that may occur with phenothiazines. There is evidence of harmful effects in animals. Appropriate monitoring and treatment of neonate born to mothers receiving prochlorperazine is recommended.

Like other drugs it should be avoided in pregnancy unless the physician considers it essential. Prochlorperazine may occasionally prolong labour and at such a time should be withheld until the cervix is dilated 3-4 cm.

Possible adverse effects on the foetus include lethargy or teenage suicide hyperexcitability, tremor and a low Apgar score. Thrombin inhibitors amounts of another phenothiazine, chlorpromazine, have been detected in breast milk, but Mitigo (Morphine Sulfate Injection)- Multum is no information available for prochlorperazine.

Consequently, it is not known whether Mitigo (Morphine Sulfate Injection)- Multum is excreted in breast milk or whether it has a Mitigo (Morphine Sulfate Injection)- Multum effect on the newborn. Therefore, prochlorperazine is not recommended for nursing mothers unless the expected benefits outweigh any potential risk. The following reactions have been reported for prochlorperazine Mitigo (Morphine Sulfate Injection)- Multum phenothiazines in vagina pulsating. Drowsiness, akathisia, parkinsonism (with dyskinesia, tremor and rigidity).

Elevated serum levels of bilirubin and hepatic enzymes may occur if the patient develops cholestatic jaundice. Peripheral oedema, cardiac arrhythmias, ECG changes, QT interval prolongation ST depression, U-Wave and T-Wave changes.



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