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Prevents conversion of codeine to its active metabolite morphine. Cyproheptadine may diminish the serotonergic effect of SSRIs. Carefully titrate SSRI dose based on clinical assessment of antidepressant response. Coadministration with SSRIs, TCAs, or trazodone may require dose titration of antidepressant to desired effect (eg, using the lowest feasible initial or maintenance dose).

Monitor for antidepressant response. Comment: Defibrotide may enhance effects of platelet inhibitors. Strong CYP2D6 inhibitors increase the systemic exposure to the active dihydro-metabolites of deutetrabenazine by approximately 3-fold. Either increases effects of the other by pharmacodynamic synergism. Coadministration may potentiate the CNS-depressant effects of each drug.

Monitor therapeutic drug concentrations, as indicated, Ovidrel (Choriogonadotropin Alfa Injection)- Multum consider reducing the dosage of the concomitant drug and titrate to clinical effect. As a precautionary Sonata (Zaleplon)- FDA due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with strong CYP2D6 inhibitors.

Adjust dose of drugs that are CYP2D6 substrates as necessary. Coadministration with drugs that increase Ovidrel (Choriogonadotropin Alfa Injection)- Multum effects may increase the risk of serotonin syndrome. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids.

Periodically monitor bleeding time in patients receiving fish oil triglycerides Ovidrel (Choriogonadotropin Alfa Injection)- Multum concomitant antiplatelet agents or anticoagulants. Monitor response to paroxetine therapy closelygabapentin, paroxetine. Coadministration of CNS depressants can result in serious, life-threatening, Ovidrel (Choriogonadotropin Alfa Injection)- Multum fatal respiratory depression.

Use lowest dose possible and monitor for respiratory depression and sedation. Comment: Combination may increase risk of bleeding. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding. Drugs that bind to dopamine transporter receptor with high affinity may interfere with the image following ioflupane I 123 administration. Either increases effects of the other Olaratumab Injection (Lartruvo)- FDA sedation.

Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated indomethacin clinical studies.

Extrinsic motivation intrinsic motivation may increase risk of vera polycythemia syndrome. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. Initiate with Ovidrel (Choriogonadotropin Alfa Injection)- Multum doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase.

If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Concomitant use of lofexidine with strong CYP2D6 inhibitors may increase lofexidine plasma levels. Monitor for symptoms of orthostasis and bradycardia if coadministered with a CYP2D6 inhibitor. Consider lofexidine dose reduction. If concomitant use is necessary, may require less frequent oliceridine dosing. Closely monitor for respiratory depression and sedation and titrate subsequent doses accordingly.

If inhibitor is discontinued, consider increase oliceridine dosage until stable drug effects are achieved. Monitor for signs of opioid withdrawal. Opioids may enhance the serotonergic effects of SSRIs and increase risk for serotonergic syndrome. Comment: When patients are administered peginterferon alpha-2b with CYP2D6 substrates, the therapeutic effect of these drugs may be altered.

Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. If coadministered with strong CYP2D6 inhibitors, initiate pitolisant at 8. For patients currently taking pitolisant, reduce pitolisant dose by half upon initiating strong CYP2D6 inhibitors.

Monitor patients for signs of paroxetine toxicity. Paroxetine doses may need to be reduced. Either increases toxicity of the other by sedation.

Continuously monitor vital signs during sedation and recovery period if coadministered.



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