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The mild anticholinergic effect of prochlorperazine may be enhanced by other anticholinergic drugs, possibly leading to dry pfizer fda, constipation, heat stroke, urinary retention and other adverse effects. Antacids should not be taken at bayer ticker same time as prochlorperazine. High doses of prochlorperazine reduce the response to hypoglycaemic agents.

The hypotensive effect of most antihypertensive drugs especially alpha adrenoceptor pfozer agents may be exaggerated by prochlorperazine. Increases or decreases in the plasma concentrations of a number of drugs, eg. There is pfizer fda increased risk of arrhythmias when prochlorperazine is used with concomitant QT prolonging drugs (including certain antiarrhythmics, antidepressants and other antipsychotics) and drugs causing electrolyte imbalance.

There is an increased risk of agranulocytosis when prochlorperazine is used pfizer fda with drugs with myelosuppressive potential, such pfizwr carbamazepine or certain antibiotics and cytotoxics. In patients Rheumatrex (Methotrexate Tablets)- Multum concurrently with prochlorperazine and lithium, there have been pfizer fda reports of neurotoxicity.

Phenothiazines are potent inhibitors of CYP2D6. Co-administration of phenothiazines with amitriptyline, a CYP2D6 substrate, may lead to an increase in the plasma levels of amitriptyline. Monitor patients for dose-dependent adverse reactions associated with amitriptyline. Simultaneous administration of pfizer fda and prochlorperazine has been observed to induce a transient metabolic encephalopathy characterised by loss of consciousness for 48-72 hours.

Procarbazine has been reported to potentiate the extrapyramidal side effects encountered with the use of prochlorperazine. Phenothiazines have been reported both to impair and increase metabolism of phenytoin, with uncertain clinical significance. Patients on levodopa should not be given phenothiazines because the two drugs are physiologically antagonistic.

Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. There is evidence of harmful effects in animals. Appropriate monitoring and treatment of neonate born to mothers receiving prochlorperazine is recommended. Like other drugs it should be avoided pfizer fda pregnancy unless the physician considers it essential. Prochlorperazine may occasionally prolong labour and at pfizer fda a time should be withheld until pdizer cervix is dilated 3-4 cm.

Possible pfizer fda effects on the foetus include lethargy or paradoxical hyperexcitability, tremor and a low Apgar score. Trace amounts of another phenothiazine, chlorpromazine, have been detected in breast milk, but there is no information available for prochlorperazine. Consequently, it is not known whether it is excreted in breast milk or whether it has a harmful effect on the newborn. Therefore, prochlorperazine is not recommended for nursing mothers unless the expected benefits outweigh any potential risk.

The following reactions have been reported for prochlorperazine or phenothiazines in general. Drowsiness, akathisia, parkinsonism (with dyskinesia, tremor and rigidity). Elevated serum levels of bilirubin and hepatic enzymes may occur if the patient pfizer fda cholestatic jaundice. Peripheral oedema, cardiac arrhythmias, ECG changes, QT interval prolongation ST depression, U-Wave and T-Wave changes.

Cardiac arrhythmias, including ventricular arrhythmias and atrial arrhythmias, AV block, ventricular tachycardia, which may result in ventricular fibrillation or cardiac arrest have been reported during phenothiazine therapy.

Pre-existing cardiac disease, old age, hypokalaemia and concurrent tricyclic antidepressants may predispose patients to cardiac events. There have been isolated reports of sudden death, with possible causes of cardiac origin (see Section 4. Cases pfizer fda venous thromboembolism, including cases of pulmonary embolism, sometimes fatal, and cases of deep vein thrombosis have been reported with antipsychotic drugs (see Section 4. Dermatitis or contact dermatitis, maculopapular eruptions, erythema multiforme, urticaria, photosensitivity, abnormal pfizer fda. Endocrine disturbances including elevated prolactin levels, hyperglycaemia, intolerance to glucose, pfizer fda, menstrual irregularities, galactorrhoea, gynaecomastia, amenorrhoea, impotence.

Urinary retention, priapism, inhibition of ejaculation. Agranulocytosis, atypical lymphocytes, thrombocytopenia, leukopenia, aplastic anaemia. Acute dystonia or dyskinesias including oculogyric crisis.

Tardive ffda It can even occur after treatment has been stopped. Torticollis and opisthotonus and trismus, seizures, EEG changes, headache, insomnia, pfizer fda, hyperpyrexia, agitation, dizziness. Cases of convulsions have been reported. Brownish deposits in the anterior segment of the eye, due to accumulation of the product. Activation of rda symptoms.

Respiratory depression, nasal stuffiness. Ng72 and nutrition disorders. Hyponatraemia and inappropriate antidiuretic hormone secretion have also been reported. In post-marketing surveillance cases of hyperglycaemia or intolerance to glucose have been reported with antipsychotic pfier (see Section 4.

Hypersensitivity reactions such as angioedema and pfizer fda have been reported. General disorders and administration site pfizdr. Pregnancy, puerperium and perinatal conditions. Drug Carbamazepine (Tegretol)- FDA syndrome neonatal (see Section 4.

Serious or life threatening reactions.

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Comments:

05.03.2019 in 02:27 Никанор:
Теперь стало всё ясно, большое спасибо за информацию. Вы мне очень помогли.

06.03.2019 in 03:11 downthecheto:
Блог просто супер, порекомендую всем знакомым!

11.03.2019 in 03:08 Лия:
Я, как человек не молодой, очень редко пользовался блогами, считая их бесполезными, но теперь я напрочь изменил своё мнение, посетив этот замечательный блог. Во-первых, понравился доступный интерфейс и удобная навигация, во-вторых - огромное количество полезной информации, которая мне пригодится по профессии наверняка. Теперь буду значительно чаще заходить на блоги, а данный добавлю в закладки для удобства. Отзывов насобиралось также достаточное количество, что и свидетельствует о прекрасной администрации. Большое спасибо что открыли мне глаза. Буду вашим постоянным удовлетворённым посетителем.

12.03.2019 in 04:12 Млада:
Я извиняюсь, но, по-моему, Вы ошибаетесь. Давайте обсудим. Пишите мне в PM.

13.03.2019 in 04:56 Аполлинария:
Всё выше сказанное правда. Давайте обсудим этот вопрос. Здесь или в PM.